When a woman’s ovaries fail to function normally and menopause occurs before the age of 40, the condition is referred to as premature ovarian insufficiency (POI). The accompanying hormonal imbalances cause symptoms such as menstrual irregularities and infertility. Mood swings, fragile mucous membranes, osteoporosis, and other complications may also occur. According to a review article published in Health Science Reports, widespread deficiencies in vitamin D, vitamin E, and selenium appear to increase the risk of premature ovarian insufficiency, whereas supplementation with these nutrients may improve ovarian function and hormonal balance.

Menopause is typically linked to hormonal changes that increase the risk of aching joints, overweight, cardiovascular disease, muscle weakness, and metabolic disturbances. According to a study published in Nutrients, however, high-dosed supplementation with fish oil for eight weeks has a positive effect on blood pressure, muscle strength, chronic inflammation, and oxidative stress, which can otherwise set the stage for atherosclerosis, joint pain, and number of chronic ailments. Earlier research has also demonstrated that fish oil supplements help against dry mucous membranes and depression that are often caused by brain inflammation.

Many women suffer from severe sleep problems during their menopause and it often reduces their work capability and quality of life. Supplementation with the natural sleep hormone, melatonin, may improve their sleep, according to a study that is published in Clinical and Experimental Obstetrics & Gynecology. The authors also mention that melatonin helps regulate the sex hormone balance and other metabolic processes that are important for good sleep.

PCOS, also known as polycystic ovary syndrome, is one of the most common hormonal disorders and can lead to infertility, male-pattern hair growth, weight gain, impaired blood sugar regulation, and an increased risk of cardiovascular disease, type 2 diabetes, and autoimmune diseases. Evidence suggests that higher blood levels of vitamin D reduce the risk of developing PCOS. This is shown in a large population-based study published in Frontiers in Nutrition, in which the authors also examine the role of vitamin D in hormonal balance, blood sugar regulation, circulation, and fertility.